VISTA Antibody

Immunology

VISTA antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human VISTA.

The immunogen is located within the last 60 amino acids of VISTA.

Cat. No. 11-533 - Human Tonsil Tissue Slide

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 8695P - VISTA Peptide

None

NP_071436

64115

VSIR

Homo sapiens

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).

Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374.

Immunofluorescence of VISTA in human tonsil tissue with B7-H5 antibody at 20 μ g/ml.