Puumala Virus Nucleocapsid Antibody

blue ice or RT

Puumala virus nucleocapsid antibody was raised against a 19 amino acid peptide near the amino terminus of the Puumala virus nucleocapsid.

The immunogen is located within amino acids 130 - 180 of Puumala Virus Nucleocapsid.

N/A

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 7693P – Puumala Virus Nucleocapsid Peptide

None

ABO93592

2943083

PUUVsSgp1

Puumala virus

Puumala virus (PUUV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) and is highly homologous to the protype hantavirus Hantaan virus (1). Like other hantaviruses, the PUUV glycoprotein is synthesized as a precursor that is posttranslationally processed into two glycoproteins G1 (Gn) and G2 (Gc). These glycoproteins interact with the PUUV nucleocapsid (NP) protein through their cytoplasmic tail, and this association has been suggested to be crucial to the binding of the ribonucleoprotein of the PUUV and the assembly of the virus particle (2).

Hepojoki J, Strandin T, Wang H, et al. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 2010; 91:2341-50.