THAP11 Antibody

159,00 €

Zzgl. MwSt.

ArtNr	PRS-7613-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Breast Cancer Head & Neck Cancer Gastric Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11
Lieferbar
Shipping	blue ice or RT
By Research Area	Stem Cell
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen	THAP11 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THAP11. The immunogen is located within the last 50 amino acids of THAP11.
Applications	THAP11 antibody can be used for detection of THAP11 by Western blot at 1 - 2 μ g/ml. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity	THAP11 antibody is human, mouse and rat reactive.
Positive Control 1	Cat. No. 1303 - Human Brain Tissue Lysate
Predicted Molecular Weight	Predicted: 35 kDa Observed: 38 kDa
Purification	THAP11 antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	THAP11 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	THAP11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 7613P – THAP11 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	THAP11
Accession #	NP_065190
Protein Gi #	40354197
Ncbi Gene Id #	57215
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	THAP11
Ncbi Official Full Name	THAP domain containing 11
Ncbi Organism	homo sapiens
Swissprot #	Q96EK4
Background	The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1). THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2). THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly(rC) binding protein PCBP1 (3).
Background References 1	Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.
Background References 2	Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.
Background References 3	Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.
1st Image Caption	Western blot analysis of THAP11 in human brain tissue lysate with THAP11 antibody at 1 μ g/ml.

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Menge: 0.02 mg

Listenpreis: 159,00 €

Preis: 159,00 €

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