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CD154 Antibody [MR1] (PE)

CD154 Antibody [MR1] (PE)

322,00 €

Zzgl. MwSt.

ArtNr	PRS-76-870-0.025mg
Hersteller	ProSci
Menge	0.025 mg
Kategorie	Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Typ	Antibody Monoclonal
Format	liquid
Applikationen	FC
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	IGM, IMD3, Ly62, TRAP, gp39, CD154, Cd40l, HIGM1, Ly-62, T-BAM, CD40-L, Tnfsf5, Cd40lg
Lieferbar
Shipping	blue ice or RT
By Research Area	Immunology
Specificity	The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality	Monoclonal
Clone	MR1
Isotype	Armenian Hamster IgG
Conjugate	PE
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	Cd40lg
Ncbi Gene Id #	21947
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Cd40lg
Ncbi Official Full Name	CD40 ligand
Ncbi Organism	Mus musculus
Swissprot #	P27548
Background	The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39. CD154 is expressed on activated T cells and plays a role in B-T cell costimulation. The interaction of CD154 with CD40 induces B cell cycle entry and the signaling for T-dependent B cell activation. By interfering with this interaction, the MR1 antibody is reported to inhibit T and B lymphocyte activation.
Background References 1	Frster, R., Kremmer, E., Schubel, A., Breitfeld, D., Kleinschmidt, A., Nerl, C., ... Lipp, M. (1998). Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation.The Journal of Immunology, 160(3), 1522-1531.
Background References 2	Schabath, R., M, G., Schubel, A., Kremmer, E., Lipp, M., Frster, R. (1999). The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation.Journal of leukocyte biology, 66(6), 996-1004.
Background References 3	Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E., Stadel, J. M. (1998). Chemokine Receptors in Human Endothelial Cells FUNCTIONAL EXPRESSION OF CXCR4 AND ITS TRANSCRIPTIONAL REGULATION BY INFLAMMATORY CYTOKINES.Journal of Biological Chemistry, 273(7), 4282-4287.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.025 mg

Listenpreis: 322,00 €

Preis: 322,00 €

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