Neprilysin Antibody

blue ice or RT

Predicted species reactivity based on immunogen sequence: Mouse, Rat, Rabbit

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50

This antibody is purified through a protein A column, followed by peptide affinity purification.

Rabbit Ig

Supplied in PBS with 0.09% (W/V) sodium azide.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

None

P08473

4311

MME

Homo sapiens

MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.

Wang, R., Wang, S. J. Neurochem. 108 (4), 1072-1082 (2009)

Shipp, M.A. Proc. Natl. Acad. Sci. U.S.A. 86 (1), 297-301 (1989)

Formalin-fixed and paraffin-embedded human kidney carcinoma with Neprilysin Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.