M Sirt3 Antibody

645,00 €

Zzgl. MwSt.

ArtNr	PRS-62-194-200ul
Hersteller	ProSci
Menge	200 ul
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot Primary Antibodies Immunostaining
Typ	Antibody Primary
Format	Liquid
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	NAD-dependent protein deacetylase sirtuin-3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, mSIR2L3, Sirt3, Sir2l3
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Shipping	blue ice or RT
By Research Area	Cancer, Cell Cycle, Obesity
Immunogen	This Sirt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-334 amino acids from the C-terminal region of Mouse Sirt3.
Applications	For WB starting dilution is: 1:2000 For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight	37 kDa
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	Sirt3
Accession #	Q8R104
Ncbi Gene Id #	64384
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Sirt3
Ncbi Official Full Name	NAD-dependent protein deacetylase sirtuin-3
Ncbi Organism	Mus musculus
Swissprot #	Q8R104
Background	SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
Background References 1	Hirschey, M.D., et al. Nature 464(7285):121-125(2010)
Background References 2	Pillai, V.B., et al. J. Biol. Chem. 285(5):3133-3144(2010)
Background References 3	Kim, H.S., et al. Cancer Cell 17(1):41-52(2010)
1st Image Caption	Western Blot at 1:64000 dilution + mouse liver lysate Lysates/proteins at 20 ug per lane.
2nd Image Caption	Western Blot at 1:2000 dilution + CHO whole cell lysate Lysates/proteins at 20 ug per lane.
3rd Image Caption	Western Blot at 1:2000 dilution + mouse liver lysate Lysates/proteins at 20 ug per lane.
4th Image Caption	Western blot analysis of lysate from mouse heart tissue lysate, using Mouse Sirt3 Antibody at 1:1000.
5th Image Caption	Western blot analysis of Sirt3 Antibody in mouse brain tissue lysates (35ug/lane)
6th Image Caption	Western blot analysis of Sirt3 Antibody in CHO cell line lysates (35ug/lane)
7th Image Caption	Sirt3 Antibody IHC analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.

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Menge: 200 ul

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Preis: 645,00 €

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