S6K Antibody

645,00 €

Zzgl. MwSt.

ArtNr	PRS-61-629-200ul
Hersteller	ProSci
Menge	200 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot Primary Antibodies Astrocytoma Immunostaining
Typ	Antibody Primary
Format	Liquid
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA
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Shipping	blue ice or RT
By Research Area	Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction
Homology	Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Immunogen	This S6K (RPS6KB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from human S6K (RPS6KB1).
Applications	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight	59 kDa
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	RPS6KB1
Accession #	P23443
Protein Gi #	54041234
Ncbi Gene Id #	6198
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	RPS6KB1
Ncbi Official Full Name	Ribosomal protein S6 kinase beta-1
Ncbi Organism	Homo sapiens
Swissprot #	P23443
Background	RPS6KB1 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding the gene for RPS6KB1 and overexpression of this kinase are seen in some breast cancer cell lines.
Background References 1	Adem, C., et al., Genes Chromosomes Cancer 41(1):1-11 (2004).
Background References 2	Suzuki, Y., et al., Genome Res. 14(9):1711-1718 (2004).
Background References 3	Gomez-Cambronero, J., et al., Leuk. Res. 28(7):755-762 (2004).
Background References 4	Raught, B., et al., EMBO J. 23(8):1761-1769 (2004).
1st Image Caption	Western blot analysis of RPS6KB1 using rabbit polyclonal RPS6KB1 Antibody (S424) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RPS6KB1 gene (Lane 2). )
2nd Image Caption	Western blot analysis of Phospho-RPS6KB1-pS424 Antibody (AP3352a) and RPS6KB1 Antibody (S424) (AP3289g) in human TNF alpha activated Hela cell line lysates. RPS6KB1 and Phospho-RPS6KB1 was detected using the purified PAb. (lane 1: without TNF alpha; lane 2: TNF alpha activated, Phospho-RPS6KB1-pS424 Antibody (AP3352a); lane 3: TNF alpha activated, RPS6KB1 Antibody (S424) (AP3289g)
3rd Image Caption	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with RPS6KB1 Antibody (T421) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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Menge: 200 ul

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Preis: 645,00 €

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