CD40 Antibody

blue ice or RT

Predicted species reactivity based on immunogen sequence: Mouse, Pig

For WB starting dilution is: 1:1000

This antibody is purified through a protein A column, followed by peptide affinity purification.

Rabbit Ig

Supplied in PBS with 0.09% (W/V) sodium azide.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

None

P25942

958

CD40

Homo sapiens

The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.

Lewis, J.P., et al. Genomics 96(4):211-219(2010)

Blanco-Kelly, F., et al. PLoS ONE(7), E11520 (2010) :

Western blot analysis in 293 cell line lysates (35ug/lane).