LASS5 Antibody

blue ice or RT

LASS5 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of the human LASS5.

The immunogen is located within amino acids 90 - 140 of LASS5.

Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.

Cat. No. 10-301 - Human Brain Tissue Slide

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 4697P – LASS5 Peptide

None

NP_671723

91012

CERS5

Homo sapiens

LASS5 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.

Lahiri S and Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J. Biol Chem.2005; 280:33735-8.

Xu Z, Zhou J, McCoy DM, et al. LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia. J. Lipid Res.2005; 46:1229-38.

Immunohistochemistry of LASS5 in human brain tissue with LASS5 antibody at 2.5 μ g/mL.