TNFRSF14 Antibody

159,00 €

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ArtNr	PRS-3773-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Antibodies Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TNFRSF14 Antibody: TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A
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Shipping	blue ice or RT
By Research Area	Herpes, Chemokines & Cytokines, Infectious Disease
Immunogen	TNFRSF14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TNFRSF14. The immunogen is located within the last 50 amino acids of TNFRSF14.
Applications	TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1207 - Raji Cell Lysate
Positive Control 2	Cat. No. 17-007 - Raji Cell Slide
Purification	TNFRSF14 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	TNFRSF14 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	TNFRSF14 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 3773P – TNFRSF14 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TNFRSF14
Accession #	Q92956
Protein Gi #	13878821
Ncbi Gene Id #	8764
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TNFRSF14
Ncbi Official Full Name	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Ncbi Organism	Homo sapiens
Swissprot #	Q92956
Background	TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κ B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.
Background References 1	Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 2005; 23:23-68.
Background References 2	Montgomery RI, Warner MS, Lum BJ, et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 1996; 87:427-36.
Background References 3	Marsters SA, Ayres TM, Skubatch M, et al. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-κ B and AP-1. J. Biol. Chem.1997; 272:14029-32.
Background References 4	Mauri DN, Ebner R, Montgomery RI, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 1998; 8:21-30.
1st Image Caption	Western blot analysis of TNFRSF14 in Raji cell lysate with TNFRSF14 antibody at 2 μ g/mL in (A) the absence and (B) the presence of blocking peptide.
2nd Image Caption	Immunocytochemistry of TNFRSF14 in Raji with TNFRSF14 antibody at 10 μ g/mL.
3rd Image Caption	Immunofluorescence of TNFRSF14 in Raji cells with TNFRSF14 antibody at 20 μ g/mL.
4th Image Caption	Western blot analysis of 5 ng of TNFRSF14 with TNFRSF14 antibody at 1 μ g/mL.

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Menge: 0.02 mg

Listenpreis: 159,00 €

Preis: 159,00 €

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