TNFSF8 Antibody

451,00 €

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ArtNr	PRS-23-648-50uL
Hersteller	ProSci
Menge	50 uL
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Hematology Leukemia Lymphoma Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Mesothelioma Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD153, CD30L, CD30LG, TNLG3A, tumor necrosis factor ligand superfamily member 8, CD153 antigen, CD30 antigen ligand, CD30 ligand, CD30-L, tumor necrosis factor (ligand) superfamily, member 8, tumor necrosis factor ligand 3A, tumor necrosis factor superfam
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Shipping	blue ice or RT
By Research Area	Apoptosis, Cell Cycle, Chemokines & Cytokines, Immunology
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 62-234 of human TNFSF8 (NP_001235.1).
Applications	WB: 1:500 - 1:2000
Positive Control 1	HepG2
Positive Control 2	B cells
Positive Control 3	Mouse liver
Positive Control 4	Rat liver
Predicted Molecular Weight	Observed: 46kDa
Purification	Affinity purification
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Conditions	Store at -20˚ C. Avoid freeze / thaw cycles.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TNFSF8
Ncbi Gene Id #	944
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TNFSF8
Ncbi Official Full Name	TNF superfamily member 8
Ncbi Organism	Homo sapiens
Swissprot #	P32971
Background	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
1st Image Caption	Western blot analysis of extracts of various cell lines, using TNFSF8 Antibody (23-648) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 50 uL

Listenpreis: 451,00 €

Preis: 451,00 €

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