Anti-Mouse CD70 - APC

Antibody Details

Product Details

Reactivity Species

Mouse

Host Species

Rat

Immunogen

BALB/c mouse B lymphoma A20.J2

Product Concentration

0.2 mg/ml

Formulation

This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This APC conjugate is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

Excitation Laser

Red Laser (650 nm)

RRID

AB_2829499

Applications and Recommended Usage?
Quality Tested by Leinco

FC The suggested concentration for this FR70 antibody for staining cells in flow cytometry is ≤ .25 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.

Additional Reported Applications For Relevant Conjugates ?

IP
B
IHC (Frozen)
For specific conjugates of this clone, review literature for suggested application details.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Clone FR70 recognizes an epitope on mouse CD70.

Antigen Distribution

CD70 is expressed by highly activated lymphocytes as found in T-cell and B-cell lymphomas.

Background

CD70 is a 30-33 kD type II transmembrane glycoprotein and a member of the TNF superfamily. CD70 is the ligand for CD27; the binding of which delivers costimulatory signals to T cells and NK cells. CD70 is expressed on highly activated lymphocytes characteristic of T- and B-cell lymphomas. Because normal lymphocytes have low CD70 expression, it has been suggested that anti-CD70 antibodies may be a possible treatment for CD70 positive lymphomas. CD70-specific antibodies are currently under investigation for the treatment of hematological malignancies and renal cell carcinoma.

Antigen Details

Protein

CD70

Ligand/Receptor

CD27

PubMed

CD70

NCBI Gene Bank ID

21948

UniProt.org

Information on Uniprot.org

Research Area

Costimulatory Molecules

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Immunology

Technical Protocols