Anti-ACE2 (17aa - Intermediate Domain)

Antibody Details

Product Details

Reactivity Species

Human

⋅

Mouse

⋅

Rat

Host Species

Rabbit

Immunogen

Anti-ACE2 antibody was raised against a peptide corresponding to 17 amino acids near the center of human ACE2. The immunogen is located within amino acids 180 - 230 of ACE2.

Product Concentration

1.0 mg/ml

Formulation

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Storage and Handling

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Country of Origin

USA

Shipping

Next Day Ambient

RRID

AB_2828098

Applications and Recommended Usage?
Quality Tested by Leinco

WB ACE2 antibody can be used for the detection of ACE2 by Western blot at 1 μg/mL.
ELISA
IF
IHC FFPE

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2) recognizes an epitope in the intermediate domain of Human and Mouse ACE2. This polyclonal antibody was purified using affinity chromatography. Anti-ACE2 has no cross response to ACE1.

Background

Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin , or the conversion of angiotensin II to angiotensin. ACE 2 has direct effects on cardiac function, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys. ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH). ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).

Antigen Details

Protein

ACE2

PubMed

ACE2

NCBI Gene Bank ID

59272

Research Area

COVID-19

.

Viral

References & Citations

1. Donoghue et al. (2000) Circ. Res. 87:1-9

2. Tipnis et al. J Biol. Chem. (2000); , 275:33238-43

3. Li et al. Nature (2003); 426:450-4

4. Lu et al. The Lancet 2020 (published online).

Technical Protocols