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Anti-Mouse CD183 In Vivo Antibody (CXCR3-173) - Ultra-Low Endotoxin [ICH1201UL]

Anti-Mouse CD183 In Vivo Antibody (CXCR3-173) - Ultra-Low Endotoxin [ICH1201UL]

3.637,00 €

Zzgl. MwSt.

ArtNr	ICH1201UL-100mg
Hersteller	IchorBio
Menge	100mg
Kategorie	Antibodies In Vivo Antibodies
Typ	Antibody Monoclonal
Applikationen	FC, NT
Clon	CXCR3-173
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Purity	>98% by SDS-PAGE and HPLC
Formula	Sterile, preservative-free, solution in PBS. BSA and Azide free.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CXCR3G, protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R ), CD183
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Specificity	CXCR3-173 activity is directed against murine CD183 (CXCR3).
Manufacturers Product Category	Ultra-Low Endotoxin, anti-mouse
Isotype Information	Armenian Hamster IgG
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution	CXCL3 is expressed on primary memory phenotype CD4+ and CD8+ T cells, naturally occurring CD4+CD25+ Foxp3+ regulatory T cells, natural killer (NK) T cells, and approximately 25% of NK cells. CXCR3-173 recognizes an epitope of CXCR3 expressed on the surface of activated mouse splenocytes.
Background	Hamsters were tested by ELISA for seropositivity against CXCR3 peptide and hybridomas were generated, screened by FACS, purified, and tested for: staining, CXCR3 blockade in vitro, and endotoxin levels. CXCR3-173 detects the native form of CXCR3, and therefore does not work in Western blotting. - - CXCR3-173 has potential use in immunotherapeutic approaches to inhibit transplant rejection and immune related diseases. In vitro, CXCR3-173 blocks chemotaxis in response to CXCL10 or CXCL11 but not CXCL9. In vivo, CXCR3-173 prolongs both cardiac and islet allograft survival in a manner further enhanced by rapamycin.
Immunogen	CXCR3-173 was generated by immunizing Armenian hamsters with a peptide sequence unique to mouse CXCR3 which encompasses amino acids 1-37.
Concentration	≥ 2.0 mg/ml
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 1%
IMPACT Pathogen Test	We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our hamster antibodies are tested for: - Mycoplasma spp - Mycoplasma pulmonis - Pneumonia virus of mice - Kilham's rat virus - Toolan's H1 virus - Hamster parvovirus - Lymphocytic choriomeningitis - Minute virus of mice - Theiler's murine encephalomyelitis virus - Sendai virus - Reovirus 3 - Hantaan virus
Storage	This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100mg

Listenpreis: 3.637,00 €

Preis: 3.637,00 €

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