IFT57 Antibody

Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2), IFT57, DERP8 ESRRBL1 HIPPI

Q9NWB7

ELISA, WB, IHC, Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

WB:1:500-1:2000

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Antigen Affinity Purified

Neuroscience