mAb anti-Tyrosine 699 Phosphorylated Human STAT5b

Tyrosine699 phosphorylated human STAT5b

Reactive to tyrosine 699 phosphorylated human STAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate, but not reactive to un-conjugated KLH or BSA.

Sp2/0-Ag14

Stat5b is a transcription factor that is activated in response to extra-cellular stimuli including IL-2, IL-4, MCSF and a variety of growth factors. In the process, receptor associated kinases phosphorylate Stat5b. Stat5b, then, forms dimers and translocates to nucleus. Inside nucleus, Stat5b binds to the promoter region on various genes to regulate biological processes such as apoptosis, T cell receptor signalling, and adult mammary gland development. Fusion of Stat5b to retinoic acid receptor-alpha (RARalpha) gene was identified in a small subgroup of acute promyelocytic leukemia patients.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Store at -20oC