NOX2 Antibody

P04839

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX2, also known as cytochrome b beta (CYBB) is one of two proteins that make up Cytochrome b-245, thought to be a primary component of the microbicidal oxidase system of phagocytes. NOX2 deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD) (2). Activation of the NOX2 enzyme complex in microglia is thought to be neurotoxic and may play a role in Alzheimer’s and Parkinson’s disease (3).

Polyclonal

CYBB (HGNC:2578)

Western blot analysis of PRDM16 in K562 cell lysate with PRDM16 antibody at 1 µg/mL.

Western blot analysis of TRIF in human lung lysate with TRIF antibody at (A) 1 and (B) 2 µg/mL.

NP_000388; 1536

65336

Rabbit polyclonal NOX2 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX2.

The immunogen is located within amino acids 140 - 190 of NOX2.

NOX2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.

NOX2 antibody can be used for detection of NOX2 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunohistochemistry starting at 2 μ g/mL. For immunofluorescence start at 20 μ g/mL.

NOX2 antibody is supplied in PBS containing 0.02% sodium azide.