Transforming Growth Factor-beta 3, TGF-beta 3 (E.coli derived), Human, Recombinant

The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-beta3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant human TGF-beta3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

0, 98

Angiogenesis/Cardiovascular, Apoptosis, Cancer, Immune System, Inflammation, Proliferation, Stem Cells &, Differentiation, TGF- beta Superfamily, Wound Healing

Endotoxin level is <, 0.1 ng/ug of protein (<, 1EU/ug).

Verified by UV Spectroscopy and/or SDS-PAGE gel.