DY131

DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. Sox2-Cre:Errbeta+/lox and Sox2-Cre:Errbetalox/lox mice treated with the Errbeta and Errgamma agonist DY131 demonstrated increased corticotropin-releasing hormone (Crh) expression in the paraventricular nucleus of the hypothalamus, although corticosterone levels were not affected. Adrenal Cyp11b1 and Cyp11b2 mRNA were increased in pregnant WT mice treated with DY131. In this study, using RNA knockdown and transcriptional activation with DY131 (an ERRgamma agonist), we clearly demonstrated that ERRgamma promotes hormone production and cell fusion indicating that ERRgamma is a key positive transcriptional factor involved in CT differentiation.

GSK 9089

C18H21N3O2

>98%