Recombinant Human IFN-alpha/beta R1 Protein

The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-αand - β . It is a cell surface receptor and heteromeric receptor composed of one chain with two subunitsreferred to as IFNAR1 and IFNAR2. IFN- α / β R1, in association with IFN- α / β R2, is required for propagatingantiviral signal transduction triggered by IFN- α and IFN- β . IFN- α / β R1 interacts very weakly or not at all withtype 1 interferons and does not stably interact with IFN- α / β R2. Ligands associate with IFN- α / β R2, and thiscomplex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γR2 even in the absence of IFN- γ stimulation. Human IFN- α / β R1 contains a nuclear localization signal in itsextracellular domain that is required for receptor translocation to the nucleus following interaction withligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.

Proteins

Lys28-Lys436

Cytokines & Cytokine receptors, Biosimilar Drug Targets

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.Contact us for customized product form or formulation.