Recombinant Human IL17RA Protein

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. This transmembrane protein (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

Proteins

Leu33-Trp320

Bio-Markers & CD Antigens, Interleukin, Biosimilar Drug Targets

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.

1.Measured by its ability to inhibit IL-17A induced IL-6 secretion by Hela cells. The ED₅₀ for this effect is 0.02 0.1 μg/mL in the presence of 10 ng/mL recombinant human IL 17A.|2.Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA , His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A, His Tag with a linear range of 31.25-65 ng/mL.